In vivo antiplasmodial activity of 11(13)-dehydroivaxillin from Carpesium ceruum
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Synthesis and antiplasmodial activity of novel phenanthroline derivatives: An in vivo study
Objective(s): Due to the rapid increased drug resistance to Plasmodium parasites, an urgent need to achieve new antiplasmodial drugs is felt. Therefore, in this study, the new synthetic phenanthroline derivatives were synthesized with antiplasmodial activity. Materials and Methods: A series of 1,10-phenanthroline derivatives containing amino-alcohol and amino-ether substituents were synthesized...
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Malaria remains o n e o f the leading causes of morbidity and mortality in tropical countries, and the alarming spread of the drugs resistant malaria parasite underscores the need to develop new antimalarial compounds. In this study, the phytochemical constituents, in vivo antiplasmodial, and cytotoxic activity of methanolic extracts of Achyranthes aspera and Ficus thoningii were evaluated usin...
متن کاملThymol derivatives from Carpesium divaricatum.
Four thymol derivatives, 2,5-dimethoxythymol (1), 2-methoxythymol isobutyrate (2), 10-isobutyloxy-8,9-epoxythymolisobutyrate (3) and 10-(2-methylbutyloxy)-8,9-epoxythymolisobutyrate (4) were isolated from the aerial parts of Carpesium divaricatum. The structures were elucidated by high field 1D and 2D NMR techniques.
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Antiplasmodial Activity of Aryltetralone Lignans from Holostylis reniformis 1 2 Valter F. de Andrade-Neto, 1-3 Tito da Silva, 4 Lucia M. Xavier Lopes, 4* Virgílio E. do Rosário, 5 3 Fernando de Pilla Varotti, 1 and Antoniana U. Krettli 1 4 5 6 Laboratório de Malaria, Centro de Pesquisas René Rachou/FIOCRUZ, 30190-002, Belo Horizonte, 7 MG, Brazil; 1 Departamento de Parasitologia, Universidade F...
متن کاملSesquiterpene lactones from Carpesium abrotanoides.
Phytochemical study on the ethanol extract of the aerial parts of Carpesium abrotanoides led to the isolation of two new sesquiterpene lactones, carabrolactone A (1) and carabrolactone B (2). Their structures were elucidated on the basis of extensive spectroscopic analysis.
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ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition and Medicinal Chemistry
سال: 2008
ISSN: 1475-6366,1475-6374
DOI: 10.1080/14756360802051610